DOES THE CYTOPLASMIC TAIL MATTER? MECHANISM OF VIRAL ENVELOPE GLYCOPROTEIN TARGETING BY MEMBRANE-ASSOCIATED-RING-CH (MARCH) PROTEINS

Does the Cytoplasmic Tail Matter? Mechanism of Viral Envelope Glycoprotein Targeting by Membrane-Associated-RING-CH (MARCH) Proteins

The MARCH family of RING-finger E3 ubiquitin ligases comprise 11 members that have been reported to play a variety of roles in the downregulation of cell-surface proteins involved in adaptive immunity.The RING-CH domain of MARCH proteins is thought to ubiquitinate the cytoplasmic tails (CTs) of target proteins, leading to protein degradation throug

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Local synaptic inputs support opposing, network-specific odor representations in a widely projecting modulatory neuron

Serotonin plays different roles across networks within the same sensory modality.Previously, we used whole-cell electrophysiology in Drosophila to show Tunnels that serotonergic neurons innervating the first olfactory relay are inhibited by odorants (Zhang and Gaudry, 2016).Here we show that network-spanning serotonergic neurons segregate informati

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